Cruising from the port of San Diego offers 72 cruise itineraries on four different cruise lines and a wide variety of destinations! You can choose to visit Cabo San Lucas, Mazatlan, Puerto Vallarta, Vancouver, or venture through the Panama Canal to Fort Lauderdale. There are aso several 14 and 15 day round trip Cruises to Hawaii.
For more info on the Hawaiian Island Cruises, click here:
Cruises from San Diego to Hawaii

Holland America Cruise Lines - ms Statendam will offer 14-day Trans Panama Canal sailings to Fort Lauderdale with ports of call in Bahia Magdalena, Puerto Vallarta, Huatulco, Puerto Chiapas, El Quetzal, Fuerte Amador, through the Panama Canal, Cartagena, and ending in Fort Lauderdale. Choose from any of these sailing dates in 2012: January 20th, February 17th, March 16th, and April the 13th. And the ms Westerdam will offer a 22-day Trans Panama Canal sailing with ports of call in Puerto Vallarta, Huatulco, Corinto, Puerto Caldera, Panama Canal, Oranjestad/Aruba, Fort Lauderdale, Half Moon Cay, Oranjestad/Aruba, Curacao, and end in Fort Lauderdale. This sailing will depart San Diego on November 3rd, 2012.

Carnival Cruise Lines - Carnival Spirit sets sail on February 12th, 26th, March 11th, 25th, and April 8th for a 5-day Mexican cruise to Cabo San Lucas and return to San Diego. The Carnival Spirit will also offer 9-day round trip Mexican cruises on March 2nd, 16th, and the 30th with ports of call in Manzanillo, Puerto Vallarta, Cabo San Lucas, Ensenada, and return to San Diego.

Celebrity Cruise Lines - Celebrity Century offers a 15-day roundtrip voyage to the Hawaian Islands on April 5th and November 19th with ports of call in Honolulu, Lahaina, Kailua Hawaii, Kilauea Volcano, Hilo, Ensenada, and return to San Diego. And on May 5th the Celebrity Century will offer an 11-day one way voyage to Canada with ports of call in Santa Catalina, San Francisco, Astoria, Victoria, Vancouver, Whistler, and end in Vancouver.

Also on December 4th the Celebrity Century will offer a 15-day Trans Panama Canal voyage with stops in Cabo San Lucas, Puerto Vallarta, El Quetzal, Puntarenas, Panama Canal, Colon, Cartagena, and end in Fort Lauderdale.